Key result
Long-term benfluorex exposure is linked to severe sub-aortic endocardial fibrosis and restrictive valvular heart disease.
Case Report (n=1)
No
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Benfluorex exposure may induce subaortic endocardial fibrosis; extends serotonergic fibrotic spectrum beyond valves but remains hypothesis-generating.
Patients exposed to benfluorex have an increased risk of restrictive organic valvular heart disease. Aortic and mitral regurgitations caused by fibrotic valve disease are the most common features observed in exposure to fenfluramine derivatives in general and benfluorex in particular. We report here, for the first time to our knowledge, a well-documented case in which obstructive sub-aortic endocardium fibrosis within the left ventricular outflow tract is related with exposure to a drug that modifies the metabolism of serotonin. It now remains to be established whether extensive fibrosis of the myocardium in addition to well-documented valvular fibrosis may develop in patients exposed to amphetamine-derived drugs affecting the serotonin system.
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Szymanski et al. (2015) conducted a case report in Sub-aortic obstruction of left ventricular outflow tract and valvular heart disease (n=1). Benfluorex was evaluated on Sub-aortic endocardial fibrosis and valvular heart disease diagnosis. A 67-year-old woman developed severe sub-aortic endocardial fibrosis and restrictive organic valvular heart disease after eight years of exposure to benfluorex.
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