The effect of additives on the morphology of spray-dried powders was investigated by using confocal laser scanning microscope (CLSM) and scanning electron microscopy (SEM). Using CLSM, the vacuoles of powder could be observed easily without ripping off the particle. The wall material was labeled with fluorescein sodium. CLSM images indicated that spray-dried powders at higher outlet temperatures have higher percentages of hollow particles. The addition of gelatin, decaglycerin monolaurate, or ethanol to gum arabic/maltodextrin (GA/MD) solution affected the increment of the percentage of hollow particles in spray-dried powders.
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Paramita et al. (2010) studied this question.
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