Key result
Lack of regular follow-up is linked to ~3.3-fold higher odds of low antihypertensive adherence.
Why the study?
Cardiovascular morbidity and mortality are increasing in Central Asia, with rural populations particularly vulnerable due to limited access to specialized care and prevention programs.
Cross-Sectional (n=1,756)
No
Odds Ratio: 3.28 (95% CI 2.36–4.56)
p-value: p=<0.001
A substantial majority of the rural population in the Kyrgyz Republic faces high or very high cardiovascular risk, compounded by severe gaps in hypertension control primarily driven by a lack of regular medical monitoring and low treatment adherence.
May support enhanced monitoring strategies in rural hypertension care; leaves open whether interventions improve adherence in similar low-resource settings.
Objective: In the Kyrgyz Republic, as in most Central Asian countries, there has been a steady increase in morbidity and mortality from cardiovascular (CV) diseases.The rural population is in a particularly vulnerable position due to the limited access to specialized medical care and prevention programs.The obejctive of the study was to evaluate the structure of CV risk and identify factors associated with low adherence to antihypertensive therapy among the adult rural population of Kemin district.Methods: A cross-sectional population study was conducted with the inclusion of 1.756 residents of rural settlements of the Kemin district aged 18 to 80 years (mean age 47.4 (12.5) years, men -27.8%).The 10-year risk of fatal CV events was assessed using the WHO/ISH scale for low-and middle-income countries (excluding laboratory parameters).The Morisky-Green questionnaire was used to assess treatment adherence.Data analysis was performed using the Pearson Chi-square test, Student's t-test, and logistic regression analysis.Results: A high (20-30%) and very high (>30%) 10-year CV risk was recorded in 62.2% of the subjects surveyed.Low adherence to therapy was found in 73.9% of patients with arterial hypertension.In the low compliance group, higher values of systolic (164.3 (12.1) vs 142.7 (8.3) mm Hg p<0.001) and diastolic (97.8 (6.9) vs 91.2 (5.1) mm Hg, p<0.001) blood pressure were reliably observed.Independent factors of low adherence were male sex (OR 2.14; 95% CI 1.58-2.89),smoking (OR 1.96; 95% CI 1.42-2.71)and lack of regular medical follow-up (OR 3.28; 95% CI 2.36-4.56). Conclusion:The study results indicate a markedly unfavorable CV risk profile among the rural population of the Kemin district, as well as an insufficient level of arterial hypertension control.This underscores the need to improve and optimize approaches to the organization of primary health care in rural areas.To improve the situation, it is recommended that structured clinic-based monitoring programs using patronage and mobile technology should be implemented with a focus on men and smokers.
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Ismarova et al. (2026) conducted a cross-sectional in Arterial hypertension and cardiovascular risk (n=1,756). Lack of regular medical follow-up vs. Regular medical follow-up was evaluated on Low adherence to antihypertensive therapy (OR 3.28, 95% CI 2.36-4.56, p=<0.001). Lack of regular medical follow-up was the strongest independent predictor of low adherence to antihypertensive therapy (OR 3.28).
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