Key result
Fruit preference linked to ~71% lower odds of ischaemic stroke.
Why the study?
Lifestyle plays an important role in the development of ischaemic stroke, but the association between combined lifestyle factors and IS risk in an eastern Chinese population was unclear.
Case-Control (n=766)
No
Lifestyle factors may refine IS risk models in eastern Chinese adults; leaves open whether targeting diet or satisfaction alters incidence in prospective trials.
PURPOSE: Lifestyle plays an important role in the development of ischaemic stroke (IS). The objective of this study was to evaluate the association between combined lifestyle factors and the risk of IS in an eastern Chinese population. METHODS: We collected lifestyle information from 191 patients with IS admitted to the second affiliated hospital of Soochow University and 575 control subjects from community clinics using a structured questionnaire. After division into training and test datasets, regularised stepwise logistic regression, least absolute shrinkage and selection operator regression and genetic algorithm models were used to identify lifestyle factors associated with IS. The improved discriminative ability by adding the lifestyle factors was determined by c-index and reclassification analysis. The final model was validated in the test dataset. RESULTS: After controlling for conventional cardiovascular disease (CVD) risk factors, preferences for fruits (OR (95% CI): 0.29 (0.18-0.46), p<0.001) and soy products (0.47 (0.29-0.75), p=0.002) were negatively associated with IS, while lower life satisfaction (mildly satisfied: 2.15 (1.27-3.63), p=0.004; not satisfied: 6.39 (1.76-25.44), p=0.006) was positively associated with IS. Adding these factors to a basic CVD risk model improved the c-index (0.825 vs 0.753, p<0.001) and reclassification for IS (net reclassification index (95% CI): 18.49% (7.90%-29.08%), integrated discrimination index (95% CI): 0.11% (0.08%-0.14%), p<0.001). The model with lifestyle factors achieved a c-index of 0.813 and good calibration in the test dataset. CONCLUSIONS: Our results showed that combined lifestyle factors including dietary pattern and life satisfaction are independently associated with the risk of IS.
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You et al. (2021) conducted a case-control in Ischaemic stroke (n=766). Combined lifestyle factors (diet and life satisfaction) vs. Control subjects was evaluated on Ischaemic stroke (associated with preference for fruits) (OR 0.29, 95% CI 0.18-0.46, p=<0.001). Preferences for fruits (OR 0.29) and soy products (OR 0.47) were negatively associated with ischaemic stroke, while lower life satisfaction was positively associated (OR 6.39; 95% CI 1.76-25.44).
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