Key result
Fas receptor binding drives enhanced virulence in the novel recombinant Echovirus 11 D5 genotype.
Why the study?
A novel recombinant Echovirus 11 strain has emerged worldwide with increased pathogenicity, particularly severe disease in neonates, but the link between genetic variations and virulence is unclear.
Answers are grounded in this paper and cite their sources.
Fas binding may inform targeted interventions for severe neonatal echovirus; leaves open clinical translation and generalizability.
A novel recombinant strain of Echovirus 11 has recently emerged worldwide and has been associated with increased pathogenicity, particularly causing severe disease in neonates. The enhanced virulence of this variant may be linked to its recombinant nature and the accumulation of mutations in capsid proteins.In this study, we investigated the relationship between genetic variations and virulence using a clinical isolate of the dominant Echovirus 11 D5 genotype, in comparison with the prototype strain.
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Sclavi et al. (2026) studied Echovirus 11 infection. Clinical isolate of the dominant Echovirus 11 D5 genotype vs. Prototype strain was evaluated on Relationship between genetic variations, Fas receptor binding, and virulence. Fas receptor binding is a key determinant of the enhanced aggressiveness and virulence of the novel recombinant Echovirus 11 D5 genotype compared to the prototype strain.
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