Key result
Skin autofluorescence correlates moderately with maximum carotid intima-media thickness in type 2 diabetes.
Why the study?
Advanced glycation end-products play a major role in diabetic vascular complications, but the association between skin autofluorescence and atherosclerosis in type 2 diabetes was not established.
Cross-Sectional (n=61)
No
Effect estimate: r = 0.407
p-value: p=0.001
Does not support clinical use of skin autofluorescence for carotid assessment in T2D; leaves open prognostic value.
Advanced glycation end-products (AGEs) are thought to play a major role in the pathogenesis of diabetic vascular complications. Skin autofluorescence (AF) was recently reported to represent tissue AGEs accumulation with a non-invasive method. The aim of the present study was to evaluate association between AF value and diabetic vascular complications, such as retinopathy, nephropathy and cervical atherosclerosis using the carotid intima-media thickness (IMT), an established marker of cardiovascular disease in patients with type 2 diabetes. A total of 68 patients with type 2 diabetes were enrolled in a cross-sectional manner. AGEs accumulation was measured with AF reader. Clinical parameters were collected at the time of AF and IMT measurement. Max-IMT was correlated with age and AF (r=0.407, p=0.001), but not with HbA1c, GA, and pentosidine. Also, AF was not correlated with HbA1c, GA and pentosidine, but was correlated with age (r=0.560, p<0.001), duration of diabetes (r=0.256, p<0.05). Multivariate regression analysis revealed that AF, but not age, was an independent determinant of max-IMT. In conclusion, AF might be a beneficial surrogate marker for evaluating carotid atherosclerosis in patients with type 2 diabetes non-invasively. J. Med. Invest. 62: 126-129, August, 2015.
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Temma et al. (2015) conducted a cross-sectional in Type 2 diabetes (n=61). Skin autofluorescence was evaluated on Correlation between skin autofluorescence (AF) and maximum carotid intima-media thickness (max-IMT) (r = 0.407, p=0.001). Skin autofluorescence, a non-invasive marker of advanced glycation end-products, was significantly correlated with maximum carotid intima-media thickness (r = 0.407) in patients with type 2 diabetes.
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