Antihyperuricemic Activity of Ethanol Extracts from Celery Plants (Apium Graveolens L.) and Bay Leaves (Syzygium Polyanthum) in Caffeine-Induced Hyperuricemic Mice Model

Celery plants (Apium Graveolens L) and bay leaves (Syzygium polyanthum) have been used as alternative medicine to treat Hyperuricemia. This study aimed to determine the effectiveness of administration of extracts from celery plants and bay leafs to decrease uric acid levels in blood. This research used a post-test control group only design. A total of 24 male mice (randomly divided into 4 groups; P0, P1, P2 and P3). P0 was the control group (induced with caffeine at a dose of 0.5 mg/kgBW). P1 was induced with caffeine 0.5 mg/kgBW+celery extract 35 mg/kgBW, P2 was induced by caffeine 0.5 mg/kgBW+bay leaf extract 35 mg/kgBW and P3 was induced by caffeine + a combination of celery plant extract and bay leaves 35mg/kgBW. Uric acid levels weremeasured using an easy touch GCU meter device. The results showed that average of uric acid level for P0, P1, P2 and P3 were 7.1mg/dl; 4.9 mg/dl; 4 mg/dl; and 5.2 mg/dl, respectively. The most significant antihyperuricemia activity was demonstrated by administering 35 mg/kgBW of bay leaf extract. The One Way ANOVA analysis described that the administration of extract ethanol of celery, bay leaves and combination generated significant effects in lowering the levels of uric acid (p-value <0.05). Based on post hoc LSD analysis, it was found that groups of P1, P2 and P3 have statistically differences in their means to P0 as well as groups of P2 to P3. However, the antihyperuricemic activity showed insignificant difference between P1- P3 and P1-P2.