Herein, we report a robust reductive coupling of cysteine thiosulfonate derivatives with aryl/alkyl halides, enabling chemoselective modification of peptides. Using zinc as the reducing agent, it provides a divergent platform for construction of Csp3/Csp2─S bonds, featuring base-free reaction conditions, operational simplicity, and broad substrate compatibility.
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Wang et al. (2026) studied this question.
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