Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling

Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics. Periprosthetic joint infection (PJI) is a complication of total joint arthroplasty mainly caused by bacterial biofilm formation and antibiotic resistance. Here, authors develop a remote-activated dynamic biomimetic system for mechanical disruption of bacterial membranes and promotion of implant osteointegration for treatment of PJI.