Interaction between C-Tb and PPD given concomitantly in a split-body randomised controlled trial

This is the authors' abstract. We don't add key points for this paper.

SETTING: Seven tuberculosis (TB) clinics in South Africa. OBJECTIVE: -specific skin test (C-Tb) contain region of difference 1 (RD1) antigens, we conducted a study to evaluate whether there was any interaction between the two during concomitant and separate administration in patients with newly diagnosed culture-positive TB. DESIGN: -TB Gold In-Tube (QFT) was performed in tandem. In patients with active TB, C-Tb sensitivity (78%) was similar to PPD (81%) and QFT (84%; excluding 82/429 [19%] indeterminate results). All tests showed reduced sensitivity in participants with CD4 <100 cells/μl. CONCLUSION: In patients with active TB, there was no interaction between C-Tb and PPD during concomitant injection of both agents. Sensitivities were similar for PPD and C-Tb.