Synthesis, characterization and antimicrobial activity of some novel 4-(4-(arylamino)-6-(piperidin-1-yl)-1,3,5-triazine-2-ylamino)-N-(pyrimidin-2-yl)benzenesulfonamides

As a part of our quest for the synthesis of new bioactive heterocyclic compounds, in our present work we have synthesized a series of 4-(4-(arylamino)-6-(piperidin-1-yl)-1,3,5-triazine-2-ylamino)- N -(pyrimidin-2-yl)benzenesulfonamide ( 3a – o ) derivatives. The newly synthesized compounds were screened for their in vitro antimicrobial activity . Compounds 3c , 3n and 3o exhibited significant antimicrobial activity on several strains of microbes. The structures of newly synthesized compounds were elucidated by IR, 1 H NMR, 13 C NMR and Mass spectral analysis.