Key result
CCR4-NOT subunit silencing, especially CNOT1, impairs cardiac structure and function across models.
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Model findings caution against targeting CCR4-NOT without further study; leaves open its role in human cardiomyopathy.
First Person is a series of interviews with the first authors of a selection of papers published in Disease Models & Mechanisms, helping early-career researchers promote themselves alongside their papers. Lisa Elmén is first author on ‘Silencing of CCR4-NOT complex subunits affects heart structure and function’, published in DMM. Lisa conducted the research described in this article while a lab manager/research associate in Rolf Bodmer's lab at Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA. She is now a scientist at Bloom Science, San Diego, CA, USA researching bacteria for the development of live biotherapeutics for neurological diseases.
A 2020 study studied Heart arrhythmia. Silencing of CCR4-NOT complex subunits (e.g., CNOT1) was evaluated.