Key result
Staphylococcus hominis native valve endocarditis can trigger severe embolic stroke despite targeted antibiotic therapy.
Why the study?
Coagulase-negative Staphylococcus is a rare cause of native-valve endocarditis, unlike its common role in prosthetic valve endocarditis.
Case Report (n=1)
Staphylococcus hominis is a rare cause of native valve endocarditis that should not be dismissed as a blood culture contaminant, as it can lead to severe embolic complications despite adequate antibiotic therapy.
May prompt consideration of S. hominis in native valve endocarditis with embolic stroke; hypothesis-generating for CoNS management beyond prosthetic valves.
Coagulase-negative Staphylococcus is a rare cause of native-valve endocarditis, while it is common in prosthetic valve endocarditis.We present a case of a patient who presented with non-specific symptoms and was found to have native valve endocarditis caused by Staphylococcus hominis, a coagulase-negative Staphylococcus.She initially presented with generalised weakness and falls and was found to be hypotensive on presentation, but otherwise hemodynamically stable.Besides a nasal bridge abrasion and nonhealing ulcer on her right heel, physical examination was not suggestive of infective endocarditis.Her white cell count was elevated, and blood cultures grew S. hominis.She had a transthoracic echo ordered as part of the workup for elevated troponin and was found to have a mitral valve vegetation.The patient was treated with cefazolin for six weeks.She developed an embolic stroke despite adequate treatment two months after the original endocarditis episode.This case highlights the importance of recognizing S. hominis as a rare cause of native valve endocarditis.
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Deeb et al. (2026) conducted a case report in Native valve infective endocarditis (n=1). Staphylococcus hominis infection was evaluated. Staphylococcus hominis can act as a rare but severe cause of native valve endocarditis, potentially leading to embolic complications such as ischemic stroke despite adequate antibiotic treatment.
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