Key result
CPET provides an integrated assessment of physiological reserve and oxygen utilization before major surgery.
Why the study?
Conventional preoperative assessment may underestimate heterogeneity in physiological reserve because resting measurements incompletely capture the response to increasing metabolic demand.
Cardiopulmonary exercise testing provides an integrated assessment of oxygen transport and utilization to better evaluate physiological reserve during preoperative assessment.
May support CPET for preoperative reserve assessment; leaves open impact on perioperative outcomes.
Major surgery imposes physiological stress requiring coordinated adaptation of the cardiovascular, respiratory, hematological, and musculoskeletal systems. Conventional preoperative assessment remains essential but may underestimate heterogeneity in physiological reserve because resting measurements incompletely capture the response to increasing metabolic demand. Cardiopulmonary exercise testing (CPET) provides an integrated assessment of oxygen transport and utilization, linking pulmonary ventilation and gas exchange to cardiovascular performance and peripheral oxygen extraction.
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Vignati et al. (2026) conducted a review in Major surgery. Cardiopulmonary exercise testing (CPET) vs. Conventional preoperative assessment was evaluated. Cardiopulmonary exercise testing (CPET) provides an integrated assessment of physiological reserve and oxygen utilization during preoperative evaluation for major surgery.
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