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DNA has proved to be a successful nanoscale building block because of its inherent programmability and its predictable structural features. One long-standing goal of DNA nanotechnology has been the rational design and assembly of three-dimensional (3D) DNA crystals for use as molecular scaffolds, in molecular electronics assembly, and as molecular sieves. Here we demonstrate that rationally designed 3D DNA crystals with mesoporous features can function as molecular sieves by selectively adsorbing proteins based on size.
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Paul J. Paukstelis (2006) studied this question.
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