Apolipoprotein E4 carrier status plus circulating anti-NMDAR1 autoantibodies: association with schizoaffective disorder

In a Letter to the Editor, Titulaer and Dalmau 1 commented on our recent publication, 2 calling for a direct response for scientific accuracy. We reported that autoantibodies against the NR1 subunit of the N -methyl-D-aspartate receptor (NMDAR-AB) are highly seroprevalent in healthy and in neuropsychiatrically ill subjects. 2 This unexpected finding has now been fully reproduced by Steiner et al. 3 who provided an addendum to their previous paper, cited by Titulaer and Dalmau, 1 revising their earlier results on healthy individuals. 4 Any further comments on this topic are thus outdated.