Key result
Higher leukocyte counts are linked to ~2-fold higher metabolic syndrome risk.
Why the study?
Leukocyte, erythrocyte, and platelet counts correlate with metabolic syndrome, and gender differences exist in these associations that warranted exploration in a Chinese population.
Are leukocyte, erythrocyte, and platelet counts associated with the prevalence and odds of metabolic syndrome differently in Chinese men and women?
Cross-Sectional (n=32,900)
No
Are leukocyte, erythrocyte, and platelet counts associated with the prevalence and odds of metabolic syndrome differently in Chinese men and women?
Answers are grounded in this paper and cite their sources.
Routine hematological counts (WBC, RBC, and platelets) are significantly associated with metabolic syndrome in Chinese adults, with platelet counts showing opposing sex-specific associations (risk factor in women, protective in men).
Leukocyte, erythrocyte or platelet and metabolic syndrome (MS) are closely correlated, and there exist gender differences. We aimed to explore the associations between the hematological parameters and MS in different genders of Chinese. This cross-sectional study included 32,900 participants (20,733 males, 12,167 females) who were enrolled in a health examination. Clinical data including anthropometric measurements and serum parameters were collected. The associations between hematological parameters and MS of both genders were analyzed separately. Odds ratio (OR) of MS was calculated by binary logistic regression models. All hematological parameters were related to MS. With leukocyte and erythrocyte counts rising, the risks of developing MS increased in both genders, which was more obvious in women. For instance, in model 3, the ORs of MS in leukocyte quartiles in females were from 1.333 to 2.045 (P < 0.01), while in males, from 1.238 to 1.675 (P < 0.01). Platelet seemed as a protective factor in males. Model 1 and model 3 in quartile 2 demonstrated ORs of 0.922 (P < 0.05) and 0.912 (P < 0.05). However, platelet acted as risk factor in female. For instance, the ORs were 1.253 (P < 0.01), 1.461 (P < 0.01), and 1.322 (P < 0.01) in platelet quartile 4 of all 3 models in female. Gender has influences on the associations between leukocyte, erythrocyte or platelet, and MS. In both genders, higher levels of leukocyte and erythrocyte increased risks of MS. For men, platelet was a protective factor, but for women, platelet seemed as a risk factor.
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Zhou et al. (2016) conducted a cross-sectional in Metabolic syndrome (n=32,900). Hematological parameters (leukocyte, erythrocyte, and platelet counts) vs. Lowest quartile (quartile 1) of leukocyte, erythrocyte, or platelet count was evaluated on Prevalence and odds of metabolic syndrome (defined by >=3 of central obesity, hypertriglyceridemia, low HDL, hypertension, or hyperglycemia) (OR 2.045, p=<0.01). Higher leukocyte and erythrocyte counts increased metabolic syndrome risk in both sexes (female leukocyte Q4 OR 2.045, P<0.01), while elevated platelets increased risk in females (OR 1.322) but were protective in males (OR 0.912).
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