Key result
CD36 rs10499859 A allele is linked to higher BMI independent of metabolic syndrome.
Why the study?
Genetic variants of the CD36 gene have been associated with metabolic syndrome (MetS), prompting this evaluation of the association between the rs10499859A>G and rs13246513C>T polymorphisms and MetS components in Iranians.
Case-Control (n=327)
No
Effect estimate: β2 = 0.68
Absolute Event Rate: 27.5% vs 26.6%
p-value: p=0.009
CD36 variants merit replication in larger cohorts; leaves open any role in metabolic syndrome risk stratification.
AIMS: The CD36 gene encodes for a membrane receptor that facilitates fatty-acid uptake and utilization. Genetic variants of the CD36 gene have been associated with metabolic syndrome (MetS). We aimed to evaluate the association between the rs10499859A>G and rs13246513C>T polymorphisms and MetS components. METHODS: For this case-control study, 140 MetS and 187 normal subjects were randomly selected from the Tehran Lipid and Glucose Study participants. Biochemical and anthropometrical variables were measured. Genotyping for both single nucleotide polymorphisms (SNPs) was performed by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: Case and control groups were not different in allele and genotype frequencies for these SNPs. However, the A and T alleles of these SNPs were significantly associated with elevated levels of high-density lipoprotein cholesterol (HDL-C) before age and sex adjustment (p=0.027 and 0.016, respectively). Association between the A allele and body mass index (BMI) was also significant after adjustment for MetS under the dominant model (p=0.009, β(2)=0.68). CONCLUSIONS: Based on our results, these polymorphisms do affect HDL-C level and BMI (MetS components), although the effect may be slight and restricted specifically to an environment-genotype.
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Zadeh–Vakili et al. (2011) conducted a case-control in Metabolic Syndrome (n=327). CD36 gene polymorphisms (rs10499859A>G and rs13246513C>T) vs. Different allele/genotype carriers and normal controls without Metabolic Syndrome was evaluated on Body mass index (BMI) association with rs10499859 A allele carrier status (adjusted for Metabolic Syndrome under dominant model) (β2 = 0.68, p=0.009). CD36 rs10499859 A allele was significantly associated with higher BMI after adjustment for metabolic syndrome (p=0.009, β2=0.68), and both SNPs were associated with unadjusted HDL-C levels.
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