Key result
Psoriatic arthritis is linked to ~2.5-point lower brachial flow-mediated dilation versus controls.
Why the study?
This study aimed to evaluate endothelial dysfunction in patients with psoriatic arthritis without risk factors for cardiovascular disease.
Case-Control (n=80)
Answers are grounded in this paper and cite their sources.
Impaired FMD in PsA without CV risks may signal early dysfunction; cross-sectional data leaves open its predictive value for events.
OBJECTIVE: To study endothelial dysfunction in patients with psoriatic arthritis (PsA) without risk factors for cardiovascular disease. METHODS: Forty patients with PsA according to Classification Criteria for Psoriatic Arthritis (CASPAR) criteria and forty age- and sex-matched controls were included. Patients with risk factors for cardiovascular disease were excluded. Endothelial function was assessed by measuring endothelial-dependent flow-mediated vasodilatation (FMD%) and endothelial-independent nitroglycerin-mediated dilatation (NMD%) in the brachial artery. RESULTS: There was a significant impairment of FMD% in patients as compared to controls (mean 8.3% vs. 10.8%, P = 0.007), but there was no significant difference in NMD%. CONCLUSIONS: There is presence of endothelial dysfunction in patients with PsA independent of risk factors for cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Sharma et al. (2014) conducted a case-control in Psoriatic arthritis (n=80). Psoriatic arthritis vs. Age- and sex-matched controls was evaluated on Endothelial-dependent flow-mediated vasodilatation (FMD%) in the brachial artery (p=0.007). Psoriatic arthritis was associated with significantly impaired brachial artery flow-mediated vasodilatation compared with matched controls (mean 8.3% vs 10.8%; P=0.007).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: