Experience in the implementation of a comprehensive non-pharmacological therapeutic program at the Center for Cognitive and Psycho-Emotional Health

Objective. To analyze the outcomes of a complex non-pharmacological treatment regimen administered to patients at the daytime hospital (DH) of the Center for Cognitive and Psycho-Emotional Health (CCPH) and to evaluate the changes in the cognitive and psycho-emotional state of the patients. Material and methods. The study included 103 patients attending the CCPH DH, with a mean age of 46.98±14.32 years; 76.7% were female. Participants were categorized into three distinct groups: Group 1 with predominantly cognitive impairments (CIs), Group 2 with predominantly psycho-emotional disorders, and Group 3 with sleep disorders. Cognitive and psycho-emotional statuses were assessed using widely accepted tests and assessment scales. Each participant underwent a tailored five-day course of non-pharmacological therapy, which integrated cognitive training, biofeedback-based electroencephalography training, physical therapy, and neurostimulation techniques. Treatment outcomes were assessed after the intervention. Results. Following the therapeutic intervention, 91.26% of participants demonstrated clinical improvement, with the greatest improvement observed in Group 2 (96.6%). No deterioration in clinical status was noted among any of the patients, thereby affirming the safety of the therapeutic interventions. Neuropsychological test results indicated a statistically significant improvement across all three groups (p<0.05), reflected in enhanced cognitive metrics and a reduction in anxiety and depressive symptoms among patients with pre-dementia CIs, anxiety disorders, and chronic insomnia. While a tendency towards improvement was noted in patients with severe ICs, the changes did not reach statistical significance, particularly in patients with isolated depressive disorders, potentially due to the limited sample size. Moreover, patients within Group 3 showed improvements in sleep during the therapy. Conclusions. The findings suggest that a five-day non-pharmacological intervention with an integrated approach represents an effective and safe method for the maintenance and enhancement of cognitive and psycho-emotional health.