Quantum-Classical Hybrid Cloud Workflows for Combinatorial Supply-Chain and Fleet Optimization

Global logistics networks, intercontinental air-freight consolidators, and maritime energy fleets continuously solve large-scale Mixed-Integer Linear Programs (MILPs) such as the Capacitated Vehicle Routing Problem with Time Windows (CVRPTW) and multi-vessel Maritime Inventory Routing Problems (MIRP). When weather disruptions, port congestion, or geopolitical airspace closures invalidate baseline schedules, classical branch-and-cut solvers (Gurobi, CPLEX) experience exponential worst-case tree growth on subproblems exceeding 2,000 binary decision variables, often failing to converge within strict 5-to-15-minute operational re-dispatch windows. Conversely, current Noisy Intermediate-Scale Quantum (NISQ) processors remain limited to 100-to-1,000 physical qubits with finite two-qubit gate fidelity ($99.2%-99.8%$), preventing direct encoding of full enterprise logistics instances. This paper presents a production-grade Quantum-Classical Hybrid Cloud Architecture that bridges enterprise Kubernetes clusters with co-located quantum processing units (QPUs) via AWS Braket Hybrid Jobs and IBM Quantum Qiskit Runtime primitives. Our framework applies Benders and Dantzig-Wolfe column generation on classical cloud HPC nodes to decompose a 25,000-variable global fleet MILP into a continuous master problem and hard combinatorial pricing/routing subproblems of 60 to 140 binary variables. These subproblems are transformed into Quadratic Unconstrained Binary Optimization (QUBO) and Ising Hamiltonians, warm-started from classical linear programming (LP) relaxations (WS-QAOA), compiled with dynamical decoupling and Zero-Noise Extrapolation (ZNE), and executed inside co-located QPU-CPU sessions while a GPU-accelerated Simulated Bifurcation (SB) digital annealer runs in parallel as a deterministic SLA fallback. Evaluated on disruption recovery workloads modeled on ExxonMobil maritime LNG routing and DHL Global Forwarding air-cargo container loading, our hybrid WS-QAOA + Column Generation workflow improves optimality gap closure at a 10-minute SLA cutoff from 6.84% (classical branch-and-bound alone) to 1.42%, reduces emergency re-routing compute wall-clock time by 61.5%, and cuts fleet fuel and charter penalty costs by 4.7%. Research Domain & Specialization Track Master of Science in Information Technology (MSIT) — Quantum Cloud Computing, Hybrid Orchestration, and Operations Research. Core Technical Highlights Empirical Production Case Studies: Rigorous architectural blueprints and telemetry evaluation across enterprise cloud deployments. Four-Tier Reference Architecture: Formal specification from edge ingress to distributed hardware execution pools. Mathematical Formulation: Formally derived algorithmic and optimization models with closed-loop verification. Multi-Modal Benchmarking: Comparative empirical baselines under fault-injection and synthetic workload scaling. Author Information Author: Sonu Kumar SinghRole: Senior Consultant Affiliation: Independent Researcher Publication Status: Preprint / Working Paper (MSIT AI & Cloud Systems Research Series) Reproducibility & Open Science All included architecture diagrams, telemetry schemas, and benchmark curves are open-access under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.