Nodosin, a new diterpenoid isolated from Isodon trichocarpus KUDO and I. Japonicus HARA, was converted to the keto lactone acetal X via several steps of reactions. The conversion made it possible to propose the structure II for nodosin. The remaining hydroxyl group proved to be located at C-11 and to have the β-configuration on the basis of a detailed NMR investigation. Thus, the structure and absolute configuration of nodosin were established as formula XIX.
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Fujita et al. (1968) studied this question.
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