Key result
Single ventricular extrastimulus reveals critical isthmus block to guide successful VT ablation.
Why the study?
Entrainment mapping is not always feasible and may terminate VT through several distinct mechanisms, requiring careful analysis of the entrainment response to differentiate local capture of the critical isthmus from other causes of termination.
Does delivery of a single ventricular extrastimulus resulting in termination with nonglobal capture identify an optimal ablation site in a patient with ischemic cardiomyopathy and recurrent ventricular tachycardia?
Case Report (n=1)
No
Does delivery of a single ventricular extrastimulus resulting in termination with nonglobal capture identify an optimal ablation site in a patient with ischemic cardiomyopathy and recurrent ventricular tachycardia?
Intentional delivery of a single ventricular extrastimulus that terminates ventricular tachycardia via nonglobal capture and bidirectional block can effectively identify a critical component of the re-entrant circuit as an optimal target for catheter ablation when concealed entrainment cannot be assessed.
Entrainment mapping, or continuous resetting of a re-entrant tachycardia, provides a powerful tool for distinguishing between focal and re-entrant ventricular tachycardias (VTs) and for identifying critical circuit components, such as the entrance, critical isthmus (CI), and exit sites. However, this technique is not always feasible and, in some cases, may itself terminate VT during the entrainment attempt. Whereas local capture of the CI without global ventricular capture (nonglobal capture [NGC]) can terminate VT by creating a bidirectional block (orthodromic or nonorthodromic capture) within the CI, the VT termination may also occur due to a rate-dependent block in the slow-conduction zone during pacing or as a result of spontaneous or mechanical trauma-related ventricular extrasystoles. Such NGC-related termination does not carry the same mechanistic implications as termination due to NGC. Although this termination is usually observed incidentally, it can also be demonstrated intentionally, eg, by delivering a single extrastimulus during tachycardia, as shown in the present case. Therefore, a careful analysis of the response to entrainment is essential.
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MERYEM et al. (2026) conducted a case report in Recurrent ventricular tachycardia and ischemic cardiomyopathy (n=1). Single ventricular extrastimulus delivery and radiofrequency catheter ablation was evaluated on Termination and non-inducibility of clinical ventricular tachycardia. Single ventricular extrastimulus delivery resulted in nonglobal capture and bidirectional block within the critical isthmus, guiding successful ablation that rendered VT non-inducible.
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