Key result
Immunosuppressive therapy linked to ~16-point LVEF improvement in cardiac sarcoidosis with ischemic stroke.
Why the study?
Patients with sarcoidosis were investigated to evaluate cardiac involvement.
Observational (n=111)
Answers are grounded in this paper and cite their sources.
Supports heightened vigilance for thromboembolic events in cardiac sarcoidosis; leaves open whether immunosuppression directly prevents recurrent stroke pending prospective studies.
Forty-one patients with sarcoidosis were investigated for cardiac involvement. The results are summarized as follows: The focal left ventricular perfusion defect was found on the TMPS's of 5 out of 41 patients with sarcoidosis. The defect disappeared in four of these five patients over a 3-year period, but remained in the patient with fatal myocardial sarcoidosis. A decreased left ventricular ejection fraction was found in 14 out of 41 patients with sarcoidosis, and in 3 out of 5 patients with the left ventricular perfusion defect. Echocardiographic examination did not reveal left ventricular wall dysfunction at the site of the left ventricular perfusion defect, except in one patient with fatal myocardial sarcoidosis. Holter ECG's showed such abnormalities as CRBBB, heart blocks, PVC, and PSC in 13 out of 32 patients with sarcoidosis. SACE activity was elevated in all three patients with the left ventricular perfusion defect that were examined, and it could be correlated with changes in the left ventricular perfusion defect in one of them.
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TACHIBANA et al. (1986) conducted an observational in Cardiac sarcoidosis with ischemic stroke (n=111). Immunosuppressive therapy and stroke management vs. Baseline (pre-therapy) was evaluated on Left ventricular ejection fraction (LVEF) improvement (p=0.043). Ischemic stroke occurred in 7.2% (8/111) of patients with cardiac sarcoidosis, and immunosuppressive therapy improved mean LVEF from 33.6% to 49.1% (p=0.043) with no stroke recurrence.
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