Trauma Dissociation, Neuroinflammation, and Hemispheric Segregation: A Comparative Theoretical Framework Linking Schizophrenia and Alzheimer's Disease

This paper proposes a theoretical framework for exploring possible relationshipsbetween early childhood trauma, emotional dissociation, and neurobiological processes associated with psychiatric and neurodegenerative conditions. Drawing fromthe Computational Agent Psychopathology Emergence (C.A.P.E.) architecture anda conceptual distinction between Primary and Secondary Personality, the frameworkexamines how unintegrated affective material, referred to here through the psychodynamic concept of the “Shadow,” may influence cognition, emotional regulation,and subjective experience.The paper compares schizophrenia and Alzheimer’s disease as distinct conditionsthat may, at a conceptual level, raise questions about the relationship betweenpsychological integration, cognitive functioning, and biological vulnerability. It alsodiscusses neuroinflammation as a possible area of investigation rather than as anestablished causal bridge between traumatic memory and neurodegeneration.A first-person account of traumatic memory re-emergence and subsequent psychological integration is presented as a subjective observation that motivated thetheoretical inquiry. The experience cannot establish the presence of neuroinflammation or demonstrate a causal relationship between trauma integration and neurologicaldisease. The proposed framework is therefore exploratory and does not constitute aclinical model, a diagnostic system, or a validated explanation of schizophrenia orAlzheimer’s disease.The central aim is to distinguish the psychological interpretation of trauma integration from claims requiring independent neurobiological evidence, while identifyingquestions that could guide future interdisciplinary research.