Summary. Two siblings of mixed Negro, East Indian and Caucasian parentage showed an abnormal haemoglobin component in infancy which had electrophoretic characteristics similar to Hb F Roma (Silvestroni & Bianco, 1963). The amino‐acid substitution responsible for the peculiar electrophoretic mobility was found to be in the gamma polypeptide chain (γ— 61(E5) Lys→Glu). The finding of an alanyl residue at position 136 of the γ‐chain of the abnormal component in the first born of these infants was repeated in the abnormal γ‐chain of the second infant. No functional abnormalities were found to be associated with this abnormal haemoglobin, which is designated Hb F Jamaica.
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Ahern et al. (1970) studied this question.
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