Analysis of factors influencing the recent efficacy of CT‑guided iodine‑125 particle implantation in patients with pancreatic cancer who were not candidates for surgical resection

To follow up patients for 6 months after CT-guided ¹²⁵I particle implantation for pancreatic cancer in patients who were not candidates for surgical resection. Postoperative tracking and follow-up for 6 months to collect relevant clinical data, the relevant factors were firstly subjected to one-way analysis, and meaningful variables were screened to be included in multifactorial logistic regression analysis. (1) A total of 84 patients were included, of which 5 had complete response (CR), 59 partial response (PR), 8 stable disease (SD), and 12 progressive disease (PD). The objective response rate (ORR) was 76.2% and the local control rate (LCR) was 85.7%; (2) The mean VAS score decreased from 5.55 ± 1.89 preoperatively to 3.69 ± 1.96 at 6 months (P < 0.001); (3) Postoperative complications requiring intervention occurred in 5 cases (bleeding 2, pancreatic fistula 1, pancreatitis 2); (4) Univariate analysis identified age and postoperative D90 as statistically significant influencing factors; tumour size, tumour stage, and particle activity showed trends toward association but did not reach statistical significance. Multivariate logistic regression showed that age, tumour size, and postoperative D90 were independent predictors of short‑term efficacy, with age and tumour size negatively correlated and D90 positively correlated with efficacy. CT‑guided ¹²⁵I particle implantation for pancreatic cancer in patients who were not candidates for surgical resection has significant short‑term efficacy, effectively relieves cancer pain, improves quality of life, and has few controllable complications. Age, tumour size, and postoperative D90 were independent predictors of short‑term efficacy; higher postoperative D90 was associated with better efficacy.