Inside Back Cover: Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

In the Communication e2953141, Stefan A. Laufer, David E. Heppner, and co-workers present the discovery of an inhibitor that pulls the strings of its target by specifically manipulating a kinase-conserved region. A self-encapsulating molecule exploits features outside the binding site and non-canonical interactions to achieve selective inhibition within a highly similar set of targets. Image by Frederik W. Hacker.