We recently showed a critical role for T cells in the immunosurveillance of nascent B cell lymphomas arising from mutations impacting plasma cell differentiation. Our data suggest that CD8+ T cells continuously eliminate mutated B cells that fail to downregulate their co-stimulatory machinery and the Fas death receptor, thus constraining B lymphoma pathogenesis.
No takes yet. Share an insight, caveat, or question.
Axel Kallies (2014) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: