Key result
X-linked ichthyosis is associated with an approximately fourfold increased risk of atrial fibrillation/flutter and a 28-35% prevalence of self-reported heart rhythm abnormalities, warranting routine cardiac screening.
Clinicians should routinely screen patients diagnosed with X-linked ichthyosis and carrier relatives for cardiac symptoms and arrhythmias to prevent severe complications such as heart failure, stroke, or sudden cardiac arrest.
X-linked ichthyosis (XLI) is a rare dermatological condition with extracutaneous features. Recently, XLI has been associated with an increased risk of cardiac arrhythmias and related conditions that may impact morbidity and mortality. This letter emphasizes the need to identify and treat cardiac issues in XLI as early as possible.
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William Davies (2025) conducted a letter in X-linked ichthyosis (XLI) and cardiac arrhythmias. Routine cardiac screening and cascade genetic/cardiac testing was evaluated. X-linked ichthyosis is associated with an approximately fourfold increased risk of atrial fibrillation/flutter and a 28-35% prevalence of self-reported heart rhythm abnormalities, warranting routine cardiac screening.
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