Endofilin A3 immunohistochemical heterogeneity in pancreatic ductal adenocarcinoma

DUCTAL ADENOCARCINOMA (abstract): Background and aim: Pancreatic ductal adenocarcinoma (PDAC) represents a malignant proliferation with minimally improved survival in last decades that presents systematic changes in classification framework based on new molecular and morphological data.Endophilin A3 (EndoA3), a protein involved in nonconventional endocytosis that was recently integrated in modulation of tumor cell adhesion molecule CD166/ALCAM, has not been evaluated in PDAC.Materials and methods: En-doA3 immunoreaction were qualitatively and semi-quantitatively analyzed in 87 cases of PDAC.Statically association between classic PDAC prognostic factors and Endophilin A3 immunohistochemical profile were evaluated.Results: Data analysis revealed that EndoA3 immunoprofile is associated with tumor degree of differentiation (p = 0.01).For the others microscopic prognostic factors there were no significant statistical correlations.Although not statistically significant, patients with high EndoA3 score presented the lowest survival.Conclusions: Endophilin A3 expressed in PDAC presents a cytoplasmic, diffuse or granular, tumor staining, but also a stromal staining.High EndoA3 immunoexpression appears to be associated with a negative prognosis in PDAC.