(opens in new window) Buy Article (opens in new window) Permissions and Reprints (opens in new window) All articles of this category (opens in new window) An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described. Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.
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Coutrot et al. (1986) studied this question.
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