The Distribution of Folic Acid Activities in Lines of Leukemic Cells of the Mouse

SUMMARY The occurrence of folate derivatives in lines P-815 and 70429 of leukemic cells and in the liver of the host, the mouse, is de- scribed. The major component detected in the leukemic cells was NnJ-formyltetrahydrofolic acid. No evidence indicating the occurrence of polyglutamyl derivatives in these leukemic cells was found. The folate distribution patterns of the leukemic cells and the mouse liver differ significantly. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. USDIN, E., J. Biol. Chem., 234, 2373 (1959). 13. MATHEWS. C. K.. AND HUENNEKENS. F. M.. J. Biol. Chem.. 14. 15. 16. 17. 18. 19. REFERENCES ROMINE, M. K., J. Vitaminology (Japan), 6, 196 (1960). SOBER, H. A., AND PETERSON, E. A., J. Am. Chem. Sot., 76, 1711 (1954). SAKAMI, W., AND KNOWLES, R., Science, 129, 274 (1959). FUTTERMAN, S., J. Biol. Chem., 228, 1031 (1957). MAY, M., CARGOS, T. J., BANGER, F. L., L~NSFORD, M., RAVEL.