Key result
Elevated CIMT, higher CRP, and low adiponectin correlate with overt coronary atherosclerosis.
Why the study?
The utility of combining biochemical markers with arterial imaging data to evaluate the presence and severity of coronary atherosclerosis needed assessment.
Cross-Sectional (n=205)
These markers may refine noninvasive evaluation; leaves open prospective validation before clinical adoption.
AIM: to assess possibilities of the use of biochemical markers combined with data of methods of imaging of arterial atherosclerotic lesions for evaluation of risk of presence and severity of coronary atherosclerosis. MATERIALS AND METHODS: We enrolled into this study patients (n=205, 136 men, 69 women, age 33-85 years, 94% on statin therapy) who underwent coronary angiography and carotid artery ultrasound dopplerography. Examination included determination of parameters of lipid profile and carbohydrate metabolism, markers of inflammation and metabolism of visceral adipose tissue. The severity of carotid artery atherosclerosis was estimated using mean common carotid artery intima-media thickness and atherosclerotic plaques presence. Severity of coronary atherosclerosis was evaluated using Gensini score. RESULTS: We found association between a number of biomarkers and severity of coronary artery involvement. Presence of coronary atherosclerosis (Gensini score >0) was associated with male sex, carotid artery stenosis >45%, and adiponectin level <8.0 pg/ml. Overt coronary atherosclerosis (Gensini score more or equal 35) significantly correlated with intima-media thickness more or equal 0.9 mm, C-reactive protein level >3.0 mg/l and adiponectin level <8.0 pg/ml.
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Metelskaya et al. (2016) conducted a cross-sectional in Coronary atherosclerosis (n=205). Carotid ultrasound imaging and metabolic/inflammatory biomarkers (intima-media thickness, stenosis, adiponectin, C-reactive protein) vs. Lower biomarker/imaging thresholds or absence of coronary atherosclerosis (Gensini score 0 or <35) was evaluated on Presence (Gensini score >0) and severity/overt (Gensini score >=35) of coronary atherosclerosis. Carotid intima-media thickness >=0.9 mm, C-reactive protein >3.0 mg/l, and adiponectin <8.0 pg/ml significantly correlated with overt coronary atherosclerosis (Gensini score >=35).
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