An individual sample predictive model to classify patients with metastatic renal cell carcinoma

Using RNAseq data from the IMmotion 151 clinical trial (IM151), 7 RCC biologic clusters have been defined. Several groups have attempted to predict clusters on RCC datasets without observing the association with therapy response from IM151. We developed IRIS-RCC (Individual RNA-seq Intrinsic Subtyping for RCC; available at https://irisrcc.vindhyadatascience.com/ ), to predict molecular clusters using an individual-sample model. IRIS-RCC normalizes gene expression within a given sample using ratiometric gene expression values.