Gastroprotective Effect of Zinc Carnosine Against Indomethacin-Induced Gastric Ulcers

Indomethacin-induced gastric injury in the rat is a standard model of non-steroidal anti-inflammatory drug toxicity, and zinc carnosine (polaprezinc) is a mucosal protective compound used clinically for gastric ulcer. This narrative review summarises what published experimental and clinical work reports about zinc carnosine in this setting. It outlines how indomethacin damages the stomach, the antioxidant, anti-inflammatory and reparative properties of the chelate, the way the model is run and scored, and the strength of the evidence. The review reports no new data. Findings are consistent with protection through antioxidant and mucosal pathways, but direct human evidence is limited and preclinical reporting often lacks randomisation and blinding.