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Small-molecule monocopper(II) catalysts mimic five enzymes: ascorbic oxidase, amine oxidase, catechol oxidase, phenoxazinone oxidase, and phosphodiesterase. Promiscuity is highest in Cu(L-NMe2)2(ClO4)2, where second coordination sphere effects govern solution geometry, reversible redox activity, substrate preactivation, and O2 activation.
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Selvakumaran et al. (2026) studied this question.
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