Key result
Captopril abolishes papaverine-induced angiotensin II spikes and cuts drinking rates over ~80% in seawater eels.
Population
Seawater eels (Anguilla anguilla)
Comparison
Papaverine administration and captopril
Supports angiotensin II mediation of drinking in eels; leaves open translation to human cardiovascular models.
The administration of papaverine (a hypotensive agent) caused an elevation in plasma angiotensin II concentration in the seawater eel, with a corresponding increase in drinking rate. Captopril completely abolished papaverine‐induced increase in drinking and reduced papaverine‐stimulated plasma angiotensin II concentrations by over 80%.
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Cramb et al. (1995) studied this question. Papaverine elevated plasma angiotensin II and drinking rates in seawater eels, effects that captopril abolished and reduced by over 80%, respectively.
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