Key result
Youth cardiometabolic risk factors are linked to greater adult carotid compression wave intensity in males.
Why the study?
Elevated carotid forward compression wave intensity is associated with accelerated cognitive decline in middle- and older-aged men, motivating the identification of its early life predictors.
Cohort
Elevated blood pressure, body weight, and fasting blood glucose in childhood and adolescence predict higher carotid forward compression wave intensity at age 28 in males, highlighting potential targets for early life cardiovascular prevention.
May inform male-specific early prevention; extends wave intensity-cognitive decline links but remains hypothesis-generating.
Elevated forward compression wave intensity in the carotid artery is associated with accelerated cognitive decline in middle- and older-aged men. This study indicates that elevated blood pressure, body weight, and fasting blood glucose throughout childhood and adolescence are associated with greater forward compression wave intensity at age 28 yr in males. This may provide novel mechanistic insight into sex-specific risk factor profiles and may guide early life prevention strategies.
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Haynes et al. (2026) conducted a cohort in Carotid forward compression wave intensity. Elevated blood pressure, body weight, and fasting blood glucose throughout childhood and adolescence was evaluated on Carotid forward compression wave intensity at age 28 years. Elevated blood pressure, body weight, and fasting glucose in childhood and adolescence were associated with greater carotid forward compression wave intensity at age 28 years in males.
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