Pediatric populations present unique anatomical challenges due to smaller vessel diameters. The purpose of this study was designed to ascertain whether the use of smart glasses with wireless ultrasound (W-US) increases first-attempt success rates compared to conventional ultrasound (C-US) in pediatric radial artery catheterization. In this randomized, controlled trial, 128 pediatric (age between 2 and 18 years) requiring radial artery catheterization under general anesthesia were allocated into either the C-US group or the W-US group. The primary outcome was first-attempt success rate. Secondary outcomes included intraprocedural maneuverability, procedure duration, and complication rates. The incidence of successful catheterization on the first attempt was higher in the W-US group than in the C-US group [86.0% vs. 70.3%; relative risk (RR) = 1.222; 95% confidence interval (CI), 1.013 to 1.474; P = 0.033]. The W-US group showed superior procedural coordination, evidenced by reduced intraoperative maneuvers: fewer head rotations (0 [0, 0] vs. 2 [2, 3]; median difference − 2; 95% CI, -3 to -2; P < 0.001), decreased ultrasound probe repositioning events (0 [0, 0] vs. 0 [0, 0]; median difference 0; 95% CI, 0 to 0; P = 0.022), and fewer needle redirections (0 [0, 0] vs. 0 [0, 1]; median difference 0, 95% CI, 0 to 0; P = 0.010). The integration of smart glasses with wireless ultrasound technology significantly improved first-attempt success rates and intraprocedural maneuverability during radial artery catheterization. The study was registered at Chinese Clinical Trial Registry (ChiCTR) with the number ChiCTR2500096195 on 20/01/2025.
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