Probable cychlorphine exposure in a patient with opioid use disorder: A case report

Background and Objectives Cychlorphine is an emerging synthetic opioid with limited clinical data. Methods We describe a patient's reported cychlorphine use and its's clinical effects. Results Thirty‐five years old male with opioid use disorder reported purchasing cychlorphine online. He described marked sedation and respiratory depression. Standard toxicology did not detect cychlorphine. Patient died 2 months later from a drug poisoning event. Discussion and Conclusion Clinicians should ask about online drug purchases and manage suspected opioid intoxication based on clinical symptoms. Scientific Significance This case highlights the risk associated with emerging NSOs, the limitations of standard and even sophisticated toxicology screening.