Preoperative mortality risk prediction and equity: Retrospective cohort validation of POSPOM in a diverse U.S. surgical population (Preprint)

Q: What does this research mean for the field?

ABHD6 regulates AMPA receptor gating kinetics by accelerating deactivation and desensitization in a TARP γ-2-dependent manner. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jackson Hall; Haley Warzecha; Chase Penhallurick; Venkatsai Bellala; Shyamal R. Asher

doi:10.2196/99623

April 28, 2026JMIR Perioperative MedicineOpen Access

Preoperative mortality risk prediction and equity: Retrospective cohort validation of POSPOM in a diverse U.S. surgical population (Preprint)

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Why the study?

Does α/β-Hydrolase domain-containing 6 (ABHD6) regulate AMPA receptor gating kinetics in the presence of TARP γ-2?

Structured PICO

Does α/β-Hydrolase domain-containing 6 (ABHD6) regulate AMPA receptor gating kinetics in the presence of TARP γ-2?

P

Population

Mammalian brain model (specifically examining GluA1, GluA2, and GluA3 homomeric and heteromeric AMPA receptors, as well as ABHD6-knockout neurons)

I

Intervention

Co-expression of α/β-Hydrolase domain-containing 6 (ABHD6) in the presence or absence of auxiliary subunit TARP γ-2, and ABHD6-knockout

C

Comparator

AMPA receptors without ABHD6 or TARP γ-2, and wild-type neurons

O

Outcome

AMPA receptor gating kinetics (deactivation, desensitization, and recovery from desensitization)surrogate

Implication

This preclinical study demonstrates that the auxiliary subunit ABHD6 regulates AMPA receptor gating kinetics in the mammalian brain specifically in a TARP γ-2-dependent manner.

Abstract

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Discussion

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Cite This Study

Hall et al. (2026) studied this question.

synapsesocial.com/papers/6ae2247b1d5c3b3dd394b087 https://doi.org/10.2196/99623

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Preoperative mortality risk prediction and equity: Retrospective cohort validation of POSPOM in a diverse U.S. surgical population (Preprint)

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Preoperative mortality risk prediction and equity: Retrospective cohort validation of POSPOM in a diverse U.S. surgical population (Preprint)

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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