Relationship of Psychiatric Disorders and Sleep Quality to Physical Symptoms in Coronary Artery Disease

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Coronary artery disease (CAD) (n=826). Intervention: Moderate/severe depression (PHQ-9 ≥10) and poor sleep quality (PSQI ≥10) vs. Normal depression score (PHQ-9 0-4) and normal sleep quality (PSQI 0-4). Primary outcome: Presence of physical symptoms (PHQ-15 score >4) (OR 4.836, 95% CI 1.261-18.545, p=0.022).

Q: What does this research mean for the field?

Moderate-to-severe depression and poor sleep quality are the strongest independent predictors of physical somatization symptoms in patients with coronary artery disease. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Anshu Peng; Ze Lin; Chunying Zhu

doi:10.1097/nmd.0000000000001478

January 12, 2022The Journal of Nervous and Mental DiseaseOpen Access

Relationship of Psychiatric Disorders and Sleep Quality to Physical Symptoms in Coronary Artery Disease

View Full Paper

Ask AI

Bookmark

Share

Key result

Depression is linked to ~4.8-fold higher odds of physical symptoms in CAD patients.

OR 4.836
95% CI 1.261-18.545
P=0.022
n=826

Why the study?

Psychiatric disorders, sleep quality, and physical symptoms are each linked to coronary artery disease, but the relationship between psychiatric disorders, sleep quality, and physical symptoms in CAD patients has been less studied.

Key Points

To examine the relationship between psychiatric disorders, sleep quality, and the presence and severity of physical symptoms in patients with coronary artery disease.
Conducted a cross-sectional observational study of 826 patients with coronary artery disease, comparing 305 patients with physical symptoms against 521 patients without physical symptoms.
Assessed physical symptoms using the PHQ-15, sleep quality with the PSQI, anxiety with the GAD-7, and depression with the PHQ-9, followed by multivariate logistic regression analysis.
Independent predictors of physical symptoms included female sex (OR, 1.419; 95% CI, 1.011–1.991; p = 0.043), age older than 65 years (OR, 2.597; 95% CI, 1.291–5.222; p = 0.007), and family history (OR, 2.191; 95% CI, 1.393–3.445; p = 0.001).
Moderate to severe sleep disorders substantially increased the odds of physical symptoms (OR, 4.528; 95% CI, 2.931–6.996; p = 0.001).
Both anxiety and depression independently predicted physical symptoms, including mild anxiety (OR, 2.405; 95% CI, 1.433–4.036; p = 0.001), moderate/severe anxiety (OR, 3.217; 95% CI, 1.113–9.293; p = 0.031), and moderate/severe depression (OR, 4.836; 95% CI, 1.261–18.545; p = 0.022).

Study Design

Type

Cross-Sectional (n=826)

PICO

P

Population

826 hospitalized patients with coronary artery disease (median age 66 years, range 25-98, 43.0% female), excluding uncooperative individuals and those younger than 25 years.

E

Exposure / Comparator

Moderate/severe depression (PHQ-9 ≥10) and poor sleep quality (PSQI ≥10) vs Normal depression score (PHQ-9 0-4) and normal sleep quality (PSQI 0-4)

O

Primary Outcome

Presence of physical symptoms (PHQ-15 score >4) — OR 4.836 (1.261-18.545), p=0.022

Main Result

Odds Ratio: 4.836 (95% CI 1.261–18.545)

Absolute Event Rate: 86.36% vs 29.29%

p-value: p=0.022

Limitations

Retrospective, cross-sectional observational design
Data collection relied on outpatient and telephone follow-ups and self-reported scales
Potential lack of generalizability and need for prospective interventional studies to determine impact on long-term outcomes

Implication

May support screening for depression and sleep issues in symptomatic CAD; leaves open whether intervention reduces physical symptoms.

Abstract

Psychiatric disorders (depression/anxiety) and sleep quality are linked to coronary artery disease (CAD). CAD patients often complain of various physical symptoms (PSs), which are not only organic changes of biological origin, but also somatization of mental illness. PSs also affect CAD progression. However, the relationship between psychiatric disorders/sleep quality and PS in CAD is less studied, which this study aims to clarify. This cross-sectional observational study was conducted on the first 305 CAD patients diagnosed with PS by Patient Health Questionnaire-15. They were compared with 521 other CAD patients showing no PS. On multivariate analysis, sex, age, family history, psychiatric disorders, and sleep quality were the significant independent predictors of PS. A significant correlation was found between PS severity and the severity of both psychiatric disorders and sleep quality. Further studies are warranted to explore the impact of psychological and sleep intervention on PS and long-term outcomes.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Peng et al. (2022) conducted a cross-sectional in Coronary artery disease (CAD) (n=826). Moderate/severe depression (PHQ-9 ≥10) and poor sleep quality (PSQI ≥10) vs. Normal depression score (PHQ-9 0-4) and normal sleep quality (PSQI 0-4) was evaluated on Presence of physical symptoms (PHQ-15 score >4) (OR 4.836, 95% CI 1.261-18.545, p=0.022). Moderate-to-severe depression (OR 4.836, p=0.022) and poor sleep quality (OR 4.528, p=0.001) were the strongest independent predictors of physical symptoms in coronary artery disease patients.

synapsesocial.com/papers/6ae23bfdcccb3bf616d5594e https://doi.org/10.1097/nmd.0000000000001478

View Full Paper

Ask AI

Bookmark

Share

Relationship of Psychiatric Disorders and Sleep Quality to Physical Symptoms in Coronary Artery Disease

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Relationship of Psychiatric Disorders and Sleep Quality to Physical Symptoms in Coronary Artery Disease

Key Points

Study Design

PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading