Key result
MS-ECG-FM outperforms existing foundation models with ~94% overall AUROC across 98 ECG diagnostic tasks.
Why the study?
Existing ECG foundation models rely solely on ECG interpretation reports for supervision, which capture only waveform information routinely recognized by clinicians and constrain representation learning to overlook broader diagnostic signals.
Does pre-training an ECG foundation model with multi-source contrastive learning across diverse clinical note types (MS-ECG-FM) improve downstream diagnostic accuracy across cardiac and systemic conditions compared to models trained solely on ECG interpretation reports?
Does pre-training an ECG foundation model with multi-source contrastive learning across diverse clinical note types (MS-ECG-FM) improve downstream diagnostic accuracy across cardiac and systemic conditions compared to models trained solely on ECG interpretation reports?
Aligning ECG waveforms with diverse clinical notes (echocardiography, chest X-ray, and discharge summaries) during pre-training enables a single ECG foundation model to accurately detect both conventional electrical abnormalities and broader structural heart and systemic diseases across 12-lead and reduced-lead configurations.
May broaden ECG detection of structural and systemic diseases; extends prior foundation models via multi-source clinical supervision.
Electrocardiography (ECG) records the electrical activity of the heart, aiding diagnosis by detecting abnormalities in cardiac function. ECG foundation models have demonstrated promising results, but are limited by a reliance on ECG interpretation reports as their sole supervision. Because interpretation reports only capture the subset of waveform information routinely recognized by clinicians, this constrains representation learning to overlook the broader diagnostic signals present in ECG. We introduce a new ECG foundation model --- MS-ECG-FM --- that is trained through contrastive alignment to multiple distinct clinical note types, including ECG, echocardiography, radiology, and discharge reports. We evaluate MS-ECG-FM on an extended set of ECG detection benchmarks, showing that it comprehensively outperforms existing methods on the full span of conditions that ECG can detect, including in reduced-lead configurations. Different reports improve representations for different diagnostic domains, while multi-source alignment captures their complementary information and produces consistently strong representations across clinically diverse tasks.
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Lewis et al. (2026) studied Cardiovascular and systemic conditions detectable by electrocardiogram (n=720,102). MS-ECG-FM (Multi-Source Electrocardiogram Foundation Model) vs. Contemporary ECG foundation models (MERL, D-BETA, MELP, ECGFounder) and a randomly initialized encoder was evaluated on Overall 12-lead ECG diagnostic classification performance (macro-averaged AUROC across 98 downstream labels). MS-ECG-FM achieved a 93.6% overall AUROC across 98 12-lead ECG diagnostic tasks, outperforming ECGFounder (91.5%), MELP (91.2%), D-BETA (90.3%), and MERL (88.8%).
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