Key result
Trait anxiety was not associated with larger physiological residue but correlated with lower peak heart rate (-0.087 SD/SD, p=0.001) and systolic pressure (-0.076 SD/SD, p=0.005).
Observational (n=848)
In an analysis of MIDUS data, the primary residue hypothesis remained untested due to a failed positive control, though secondary analyses revealed trait anxiety was cross-sectionally associated with blunted peak heart rate and systolic blood pressure responses rather than a larger residue.
Null positive control replication cautions against protocol use; leaves open simplified replication of 2018 effect.
Result of the sealed preregistration NQF-2026AH (version 1.0, DOI 10.5281/zenodo.23303495), run on 11 October 2026 with the sealed executor (MD5 d3d67798999b6ece26e97494ac60a0c3, listed in version 2 as “ejecutor_2026AH (1).py” after a browser renaming) on the six MIDUS files of the pinned repository commit, whose MD5 are printed below. Registered reading: the verdict of the protocol, the primary outcome on the primary channel, is NEITHER, and it is non-informative because the positive control C1 failed (simplified replication of Leger, Charles and Almeida 2018: beta −0.036, z −0.38, n 848). Every NEITHER of the outcome arms is a registered failure to detect, not a refutation; the residue claim stays untested. C2 passed (age predicts death, z 12.9), and the residue was measured reliably within the morning (Spearman–Brown 0.72 on heart rate). In the secondary mechanism arm, which predicts no outcome and is read by its own section, trait anxiety did not go with a larger residue on any channel (every 90 per cent interval inside ±0.10 SD per SD) and went with a lower peak on heart rate (−0.087 SD per SD, one-sided p 0.001) and systolic pressure (−0.076, p 0.005): registered row BLUNTED_PEAK_ONLY. It is an association at one visit, not a cause, and the finding a replication should test.
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Juan Carlos Madrid Vites (2026) conducted an observational in Trait anxiety and physiological stress residue (n=848). Trait anxiety and physiological stress residue vs. Peak physiological response and positive controls was evaluated on Primary outcome on the primary channel (verdict: NEITHER, non-informative due to positive control C1 failure) (beta -0.036). Trait anxiety was not associated with larger physiological residue but correlated with lower peak heart rate (-0.087 SD/SD, p=0.001) and systolic pressure (-0.076 SD/SD, p=0.005).
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