Key result
Residual stenosis over 30% after DCB angioplasty linked to ~11.7-fold higher late restenosis risk.
Why the study?
The study aimed to analyze the factors influencing late-stage lumen restenosis after coronary drug-coated balloon angioplasty.
Do a history of hypertension and immediate postoperative residual lumen stenosis >30% increase the risk of late-stage lumen restenosis at 6–12 months in patients with coronary artery disease undergoing coronary drug-coated balloon angioplasty?
Cohort (n=137)
No
Do a history of hypertension and immediate postoperative residual lumen stenosis >30% increase the risk of late-stage lumen restenosis at 6–12 months in patients with coronary artery disease undergoing coronary drug-coated balloon angioplasty?
This retrospective cohort study demonstrates that a history of hypertension and immediate post-procedural residual lumen stenosis >30% are strong, independent predictors of late-stage lumen restenosis at 6–12 months following coronary drug-coated balloon angioplasty.
Objective: To analyze the factors influencing late‐stage lumen restenosis (LSLR) after coronary drug‐coated balloon (DCB) angioplasty based on logistic regression analysis. Methodology: This was a retrospective study. Patients diagnosed with coronary artery disease (CAD) who underwent percutaneous coronary DCB angioplasty at Cangzhou People’s Hospital from January 2021 to December 2024 and underwent follow‐up coronary angiography 6–12 months postoperatively were selected. The patients were divided into the LSLR group (n = 41) and the non‐restenosis (NR) group (n = 96). Clinical data of both groups were compared, and binary logistic regression analysis was conducted to determine the influencing factors for LSLR after coronary DCB angioplasty. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive value of relevant parameters for LSLR after coronary DCB angioplasty. Results: There were no statistically significant differences between the two groups in sex, age, history of diabetes, primary vessel lesion lumen diameter, preoperative target lesion stenosis degree, presence of calcification in the target lesion before surgery, use of intravascular ultrasound assistance during surgery, occurrence of postoperative coronary dissection or thrombosis, and levels of total cholesterol, low‐density lipoprotein, and lipoprotein(a) at the second follow‐up angiography (all P > 0.05). However, significant differences were found in history of hypertension and immediate postoperative residual lumen stenosis (IPRLS) >30% between the two groups (P < 0.05, respectively). Binary logistic regression analysis indicated that a history of hypertension and IPRLS >30% were independent risk factors for LSLR after coronary DCB angioplasty (P < 0.05, respectively). ROC curve analysis showed that the area under the curve for history of hypertension and IPRLS >30% were both >0.700, suggesting that these parameters are highly predictive of LSLR following coronary DCB angioplasty. Conclusion: A history of hypertension and IPRLS >30% are independent risk factors for LSLR after coronary DCB angioplasty.
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Wang et al. (2026) conducted a cohort in Coronary artery disease treated with drug-coated balloon angioplasty (n=137). Immediate postoperative residual lumen stenosis (IPRLS) >30% vs. IPRLS <=30% was evaluated on Late-stage lumen restenosis (LSLR >=50%) at 6-12 months follow-up coronary angiography (OR 11.670, 95% CI 5.740-23.725, p=<0.001). Immediate postoperative residual lumen stenosis >30% (OR 11.670) and hypertension history (OR 3.997) independently predicted late-stage lumen restenosis after coronary DCB angioplasty.
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