Key result
DOACs are preferred for primary cardioembolic stroke prevention in most patients with AF.
Why the study?
Atrial fibrillation is a major risk factor for cardioembolic stroke due to impaired atrial contraction and thrombus formation. This thesis highlights the clinical significance of primary prevention of cardioembolic stroke and anticoagulant therapy in patients with atrial fibrillation.
This thesis highlights that primary prevention of cardioembolic stroke in atrial fibrillation relies on individualized thromboembolic and bleeding risk assessment, with direct oral anticoagulants preferred for most indicated patients.
Answers are grounded in this paper and cite their sources.
Individualized thromboembolic risk assessment guides anticoagulation in AF; leaves open prospective validation of primary prevention strategies.
Atrial fibrillation is one of the major risk factors for cardioembolic stroke. In this arrhythmia, impaired effective atrial contraction leads to slower blood flow and an increased likelihood of thrombus formation. The aim of this thesis is to highlight the clinical significance of primary prevention of cardioembolic stroke and anticoagulant therapy in patients with atrial fibrillation. Preventive strategies place particular emphasis on the individual assessment of thromboembolic risk, consideration of patients’ comorbidities, and reduction of bleeding risk. According to current clinical guidelines, direct oral anticoagulants are preferred for most patients when indicated. However, the choice of medication depends on the condition of the heart valves, renal function, drug interactions, and other clinical factors.
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Sultonmurodov Baxtiyorjon (2026) conducted a review in Atrial fibrillation. Anticoagulant therapy (direct oral anticoagulants) was evaluated on Primary prevention of cardioembolic stroke. Direct oral anticoagulants are preferred for primary prevention of cardioembolic stroke in most patients with atrial fibrillation, tailored to valve status, renal function, and bleeding risk.
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