Acute Myocardial Infarction Following Tenecteplase: A Case Report of Complex Dual Pathology

Introduction: Acute ischemic stroke is a leading cause of morbidity and mortality, with tenecteplase being a cornerstone of acute management. While tenecteplase carries a known risk of bleeding, major thrombotic events such as acute myocardial infarction (AMI) after stroke reperfusion are less commonly described. Case Report: We present the case of a 67-year-old man who presented with acute stroke symptoms. After ruling out intracranial hemorrhage and managing blood pressure, he received tenecteplase, and all neurological deficits resolved. Soon after, he developed acute chest pain, and his repeat electrocardiogram confirmed a ST-elevation myocardial infarction. He underwent emergent cardiac catheterization, revealing 100% occlusion of the left circumflex artery, which was successfully revascularized with thrombectomy and angioplasty. Intravascular ultrasound further supported the presence of embolic phenomenon. Pathology of the retrieved material identified thrombus alongside atherosclerotic plaque fragments. The patient experienced complete symptom resolution and was discharged after a short hospitalization.This case highlights the complexities encountered when a patient with acute ischemic stroke who is treated with tenecteplase subsequently develops an AMI. Potential mechanisms include a coincidental plaque rupture, possibly exacerbated by the stress of the acute stroke, a rare paradoxical prothrombotic effect of thrombolysis, or a combination thereof. The pathological finding of mixed thrombus and atherosclerotic plaque underscores the underlying disease contributing to this event. Conclusion: This case accentuates the importance of maintaining a high index of suspicion for new cardiovascular events in post-thrombolysis patients, especially those with significant cardiovascular risk factors. Rapid and judicious diagnostic evaluation is crucial for timely management of these complex, life-threatening complications.