Llevemos al uso practico el concepto de Centreel

This is the authors' abstract. We don't add key points for this paper.

Chronic stress is a major contributor to physiological dysregulation, associated with neuroendocrine, metabolic, immunological, and emotional disturbances that compromise the body's adaptive and self-regulatory capacities. From the perspective of Systems Bioregulatory Medicine (BrSM), addressing chronic stress requires understanding the dynamic interactions among biological networks, particularly the hypothalamic-pituitary-adrenal (HPA) axis, the autonomic nervous system, and the extracellular matrix.Objective: To explore the pathophysiological mechanisms of chronic stress and present clinical intervention strategies from an integrative, multicomponent, and multitarget perspective aimed at restoring functional balance.Content: The progression from adaptive stress responses to allostatic overload, circadian rhythm disturbances, metabolic dysfunction, and persistent inflammation is examined. Illustrative clinical cases highlight different pathways of dysregulation, including sustained psychosocial stress, chronobiological disturbances, and hormonal and metabolic imbalances. The extracellular matrix is emphasized as an active component of cellular communication and regulation. Furthermore, the BrSM therapeutic approach is presented, focusing on identifying barriers to self-regulation, modulating dysregulated biological networks, and supporting the organs and tissues involved. Bioregulatory pharmacological approaches, including Centreel®, Matriceel®, and other complementary interventions, are discussed in relation to their theoretical foundations, proposed clinical applications, and the need for critical evaluation of supporting evidence.Conclusion: Chronic stress is a systemic phenomenon whose clinical manifestations extend beyond emotional symptoms. Identifying individual patterns of dysregulation may guide comprehensive clinical decision-making by integrating lifestyle interventions, chronobiological strategies, and complementary therapeutic approaches. BrSM provides a systems-oriented framework focused on biological network interactions, although its specific therapeutic effectiveness requires further validation through rigorous clinical research.