Key result
Intravenous rt-PA administered 4.5-6 hours after acute ischemic stroke onset achieved 90-day favorable outcomes (mRS 0-1) comparable to treatment within 4.5 hours (51.7% vs 53.1%; P=0.8905).
Why the study?
This study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator administered at different time windows within the first 6 hours after acute ischemic stroke onset.
Observational (n=223)
No
Retrospective study finds comparable recovery and mortality between early and extended thrombolysis windows in acute ischemic stroke, suggesting rt-PA remains viable up to six hours.
We aimed to compare the therapeutic effect of recombinant tissue plasminogen activator (rt-PA) administered at different time windows within the first 6 hours after onset of acute ischemic stroke (AIS). A retrospective analysis was performed of data collected from 194 patients who received rt-PA thrombolysis within 4.5 hours after AIS onset and from 29 patients who received rt-PA thrombolysis between 4.5-6 hours after AIS onset. The National Institutes of Health Stroke Scale (NIHSS) scores were statistically decreased in both groups (P < 0.05) at 24 hours and 7 days after onset. There was no statistical difference in the modified Rankin score or mortality at day 90 after treatment between the two groups (P > 0.05). In conclusion, AIS patients who received rt-PA treatment between 4.5-6 hours after onset were similar in therapeutic efficacy to those who received rt-PA within 4.5 hours after onset. Our results suggest that intravenous thrombolytic therapy for AIS within 4.5-6 hours after onset is effective and safe.
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Wang et al. (2015) conducted an observational in Acute ischemic stroke (n=223). Intravenous recombinant tissue plasminogen activator (rt-PA) administered at 4.5-6 hours after symptom onset vs. Intravenous rt-PA administered within 0-4.5 hours after symptom onset was evaluated on Favorable functional outcome (modified Rankin Scale score 0-1) at 90 days (p=0.8905). Intravenous rt-PA administered 4.5-6 hours after acute ischemic stroke onset achieved 90-day favorable outcomes (mRS 0-1) comparable to treatment within 4.5 hours (51.7% vs 53.1%; P=0.8905).
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